NAD+ side effects: reported reactions and safety questions
FDA has received reports of severe chills, shaking, vomiting and fatigue after injectable NAD+ drugs, with some patients requiring medical treatment. The agency describes these reactions as consistent with excessive endotoxins and warns about unsuitable food-grade ingredients used in sterile compounding. These reports do not establish how often reactions occur or that every NAD+ preparation has the same risk. Read FDA's NAD+ compounding notice[3].
Product quality, dose, route and infusion rate are separate questions. Ask the prescribing clinician about risks and suitability, and the dispensing pharmacy about the actual preparation. The price analysis below explains another limit: 250 of 377 offers from 107 sellers read in September 2026 state no dose beside the price. Those price records are not adverse-event evidence.[1][2]
Reported reactions are not a complete side-effect rate
An adverse-event report is a safety signal, not a controlled comparison proving how frequently an event occurs or what caused it in every case. FDA's notice concerns ingredient suitability and potential contamination. It should not be reduced to a claim that any reaction is merely a normal effect of a higher dose or a faster infusion.[3]
FDA also explains that compounded drugs are not FDA-approved[4]: the agency does not verify their safety, effectiveness or quality before marketing. A prescription or pharmacy license is not the same as FDA approval of the finished preparation. Ask which pharmacy dispenses the prescription and who handles a clinical concern before starting care.
This page does not provide a personalized risk assessment or a dosing schedule. A low price, a stated milligram total and a successful payment do not establish that a product is suitable for you. The provider checklist helps separate questions about the care arrangement from the price comparison.
A dose-dependent effect needs a dose
Knowing the amount purchased is necessary for understanding a quote, but it is not sufficient for assessing safety. A price list cannot resolve contamination, suitability or the appropriate dose. It can show whether the seller states the amount at all.
Prices stating a dose of any kind
127 of 377
Distinct prices stating enough to compute a milligram total
18 of 345 — 55 more were examined and refused
Prices a reader can actually see on the seller's page
336 of 377 — 41 exist only in the markup
From the prices read in September 2026. A price counts as stating a dose only where the seller printed one beside it; nothing is read out of the surrounding page, where a shipping weight or a vial size would pass for a dose. The empty part of each track is the finding.
The gap between the first bar and the second is the interesting one. 127 prices state something about dose. Far fewer state something a person can turn into a number, because “a dose” in this market includes concentrations with no volume beside them, ranges, ceilings, vial sizes and titration schedules. Each of those is a real answer to “how much is in it” and none of them is a total.
Two sessions, one name, 2 times the load
Where doses are printed, the spread between products sharing a name is the thing worth seeing. Garcia Weight Loss, Aesthetics & Hormone Therapy lists two infusions side by side:
$250.00 for 250 mg, and $500.00 for 500 mg — both listed as an NAD+ infusion, both “per infusion”.
Those are honest listings and they are unusually good ones: the milligrams are printed beside the money, which is all this site ever asks of a seller. The point is what they reveal about everyone else. A reader who books “an NAD+ infusion” without checking could receive either, and the two differ by a factor of 2 — 250 mg against 500 mg, both totals these listings state themselves. These are purchase quantities, not evidence of a safe dose or a predictable clinical response.
Compare Modern Age, a second clinic in the same roster pricing the same route:
$750 for “1 session” — with no dose stated.
$750 against $500.00 looks like a price comparison. It is not one, because only one of the two says what is in the bag. This site will not divide the first figure by anything, will not estimate its milligrams, and leaves it off the cost-per-milligram board rather than guessing it onto the axis.
Why the route decides the load
The other reason a dose is hard to reason about here is that the routes are not delivering comparable quantities on comparable schedules. An infusion puts a large amount in over an hour. A subcutaneous plan spreads a much smaller amount across a month. A nasal spray is a third pattern again.
of the 377 prices in the roster
Counted from the route each seller names on its own page, read in September 2026. The scale is the whole roster rather than the tallest row, so two charts on this site can be read against each other.
110 of the 377 prices do not say which of these they are. For those, a buyer knows neither the amount nor the delivery pattern, which are the two variables the whole “start low, go slow” idea is built on.
This is also why cost per milligram is worth computing and worth reading carefully. $700.00 for a package of three IV infusions, delivering 750 mg and a monthly subcutaneous plan are the same kind of number once divided, and they are still not the same experience. The board prints the route on every row for exactly that reason.
What we refuse to do with these numbers
We also refuse to estimate a missing dose. It would be easy to take a seller’s “1000 MG/ML” and multiply it by a vial size we assumed, and the resulting milligram total would be indistinguishable on the page from one a seller stated. Of the 73 distinct prices that stated a dose and could plausibly have been turned into a total, 18 were admitted and 55 were refused, each under a named rule. On the prices that survived, 13 of the milligram totals are the seller’s own and the remaining 5 are our multiplication, and say so wherever they appear.
Why 55 prices that state a dose still have no milligram total
Every refusal is recorded against a named clause rather than a general “insufficient data”. All 55 of them, largest clause first:
- 18 of 55
- the seller states a strength and a billing cycle but never how many of the unit the cycle buys
- 16 of 55
- the figure is a “from” or “starting at” price, so the milligrams attach to a number nobody is necessarily charged
- 11 of 55
- the figure is a first-period price, which is not what the unit costs from the second month on
- 6 of 55
- the dose is a volume, a concentration with no volume, a range, a ceiling or a titration schedule, so no total milligram figure exists
- 2 of 55
- the page states more than one cycle for this figure and never says which one governs
- 1 of 55
- the seller’s own words put the billing cycle and the supply on different clocks
- 1 of 55
- the milligrams are stated for the subscription plan but not for the one-off purchase
Every dose-bearing price is ruled on one at a time, so a price cannot quietly appear on the board or drop off it.
250 of 377
prices stating no dose at all
18 of 345
distinct prices with a computable milligram total
110 of 377
prices naming no route
41 of 377
figures present in the markup but never shown
What adverse reactions has FDA reported after injectable NAD+?
FDA reports severe chills, shaking, vomiting and fatigue, with some patients requiring medical treatment. These reports are consistent with excessive endotoxins; they do not establish a complete symptom list, frequency or your individual risk. See the linked FDA notice and discuss clinical concerns with your prescribing clinician.[3]
Why not just estimate the dose from the concentration?
Because a concentration without a volume is not a quantity. “1000 MG/ML” becomes a milligram total only once you assume a vial size, and an assumed number looks exactly like a stated one on a finished page. Every milligram total on this site is either the seller’s own or our multiplication of two figures they printed, and it says which.
How do I compare two clinics if neither states a dose?
You cannot, on cost per milligram, and this site will not pretend otherwise. What you can do is ask each of them for the milligrams before booking, and then run both answers through the calculator, which does the division and keeps its arithmetic independent of its disclosed partner panel.
Are these prices still current?
They were read in September 2026 and carry that date wherever they appear. A verification date lets you judge how recently a price was checked. This roster was read on a single day, so it can tell you exactly when — and nothing at all about how prices have moved since.
Sources
- nadcost provider price records Historical seller observations captured in September 2026. Individual records distinguish later checks; these prices do not establish clinical safety or effectiveness.
- nadcost editorial policy and calculation method How stated quantities, qualifications and dates are preserved, and when a cost-per-milligram calculation is possible.
- FDA: ingredients suitable for sterile compounding and reported injectable NAD+ adverse events
- FDA: compounding questions and answers